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LMK-235

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SL-1610

LMK-235, >98%

CAS No. : [1418033-25-6]

MDL No. : MFCD26522892

IUPAC Name : N-((6-(Hydroxyamino)-6-oxohexyl)oxy)-3,5-dimethylbenzamide

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Chemical Properites
Mol. Formula :
C15H22N2O4
Mol. Weight :
294.35
Appearance :
Off-white solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : LMK-235 is a potent HDAC inhibitor, inhibits HDAC5, HDAC4, HDAC6, HDAC1, HDAC2, HDAC11 and HDAC8, with IC50s of 4.22 nM, 11.9 nM, 55.7 nM, 320 nM, 881 nM, 852 nM and 1278 nM, respectively. It is used in cancer research.

References : Marek L. et al.: J Med Chem., 56(2), 427-436, 2013; Li A. et al.: Oncotarget., 7(25), 37966-37978, 2016; Trazzi S. et al.: Hum. Mol. Genet., 25(18), 3887-3907, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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