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Loperamide-d6 N-oxide

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SL-3473

Loperamide-d6 N-oxide, >98% (CP)

Isotopic Purity : 99 atom % D

CAS No. : [1329835-39-3]

IUPAC Name : 4-(4-Chlorophenyl)-1-(4-((dimethyl-d6)-amino)-4-oxo-3,3-diphenylbutyl)-4-hydroxypiperidine 1-oxide

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Chemical Properites
Mol. Formula :
C29H27D6ClN2O3
Mol. Weight :
499.07
Appearance :
Off-white solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Loperamide-d6 N-oxide is a deuterium labelled version an impurity of Loperamide (Loperamide-d6 N-oxide), which is a selective μ-opioid receptor agonist, used against diarrhea resulting from gastroenteritis or inflammatory bowel disease.

References : DeHaven-Hudkins D. L. et al.: J. Pharmacol Exp Ther., 289(1), 494-502, 1999; Quinney S. K. et al. J. Pharmacol Exp Ther., 313(3), 1011-1016, 2005; Church J. et al.: Mol. Pharmacol., 45(4), 747-757, 1994.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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