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Loperamide EP impurity G

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Loperamide EP impurity G, >98%

CAS No. : [109572-89-6]

Synonyms : cis-4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamide-1-oxide; cis-Loperamide N-oxide

IUPAC Name : (1s,4r)-4-(4-Chlorophenyl)-1-(4-(dimethylamino)-4-oxo-3,3-diphenylbutyl)-4-hydroxypiperidine 1-oxide

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Chemical Properites
Mol. Formula :
C29H33ClN2O3
Mol. Weight :
493.04
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Loperamide (Loperamide EP impurity G), which is a selective μ-opioid receptor agonist, used against diarrhea resulting from gastroenteritis or inflammatory bowel disease.

References : DeHaven-Hudkins D. L. et al.: J. Pharmacol Exp Ther., 289(1), 494-502, 1999; Quinney S. K. et al. J. Pharmacol Exp Ther., 313(3), 1011-1016, 2005; Church J. et al.: Mol. Pharmacol., 45(4), 747-757, 1994.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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