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Lorlatinib

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SI-5266

Lorlatinib, >98% (HPLC)

CAS No. : [1454846-35-5]

MDL No. : MFCD28144520

Synonyms : PF-06463922

IUPAC Name : (R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile

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Chemical Properites
Mol. Formula :
C21H19FN6O2
Mol. Weight :
406.42
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Lorlatinib is a selective, orally active, brain-penetrant and ATP-competitive ROS1/ALK inhibitor. It is used for the potential treatment of non-small cell lung cancer (NSCL).

References : Johnson T. W. et al.: J. Med Chem., 57(11), 4720-44, 2014; Zou H. Y. et al.: Proc Natl Acad Sci U S A. 112(11), 3493-8, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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