Lorlatinib-d3

SI-5568

Lorlatinib-d3, >98% (HPLC)

Isotopic Purity : 99 atom % D

CAS No. : [2131126-22-0]

Synonyms : PF-06463922-d3

IUPAC Name : (R)-26-Amino-55-fluoro-11,4-dimethyl-7-(methyl-d3)-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
Note: Lorlatinib-d3 is not in stock but can be available through custom synthesis. The estimated lead-time is 4-6 weeks. The product will be characterized by NMR and Mass analysis. Purity (HPLC) is usually >98%. COA, QC data and SDS will be provided along with the product. For information on pricing and availability please contact us atsales@syninnova.com or Request A Quote. We respond promptly. Thank You!

Applications : Lorlatinib-d₃ is a deuterium labelled version an analog of Lorlatinib, which is a selective, orally active, brain-penetrant and ATP-competitive ROS1/ALK inhibitor. Lorlatinib has Kis of <0.025 nM, <0.07 nM, and 0.7 nM for ROS1, wild type ALK, and ALKL1196M, respectively. Lorlatinib has anticancer activity.

References : Johnson T. W. et al.: J Med Chem., 57(11), 4720-44, 2014; Zou H. Y. et al.: Proc Natl Acad Sci U S A. 112(11), 3493-8, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.