Lornoxicam impurity 16

SL-10927

Lornoxicam impurity 16, >98%

CAS No. : [70374-37-7]

IUPAC Name : Methyl 5-chloro-3-((methylamino)sulfinyl)thiophene-2-carboxylate

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Applications : This is an impurity of Lornoxicam, which is an orally active NSAID with analgesic, anti-inflammatory, antipyretic, and anticancer properties. It inhibits COX-1 (IC50=0.005 μM) and COX-2 (IC50=0.008 μM), suppresses NO production by iNOS (IC50=65 μM), reduces IL-6 (IC50=54 μM), and curbs tumor cell growth and migration. Lornoxicam may be studied for inflammatory pain, colorectal cancer, and breast cancer.

References : Spyra S. et al.: Br. J. Pharmacol., 174(16), 2696-2705, 2017; Rose P. et al.: Clin Drug Investig., 24(4), 227-36, 2004; Bianchi M. et al.: Pharmacol Res., 45(2), 101-105, 2002; Balfour J. A. et al. Drugs 51, 639-657, 1996; Pohlmeyer-Esch G. et al.: Food and chemical toxicology, 35(9), 909-922, 1997; Berg J. et al.: Inflammation Research., 48, 369-379, 1999; Marinov L. et al.: Pharmacia, 71, 1-12, 2024.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.