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Lotiglipron

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SI-8071

Lotiglipron, >98% (HPLC)

CAS No. : [2401892-75-7]

Synonyms : PF-07081532

IUPAC Name : 2-((4-((S)-2-(5-Chloropyridin-2-yl)-2-methylbenzo[d][1,3]dioxol-4-yl)piperidin-1-yl)methyl)-1-(((S)-oxetan-2-yl)methyl)-1H-benzo[d]imidazole-6-carboxylic acid

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Back Order  Estimated to ship on 04 October 2026
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Chemical Properites
Mol. Formula :
C31H31ClN4O5
Mol. Weight :
575.06
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Lotiglipron is an orally active small‑molecule GLP‑1 receptor agonist that enhances GLP‑1R‑mediated cAMP signaling to lower glucose and reduce body weight. It serves as a useful research tool compound for studying type 2 diabetes mellitus (T2DM) and metabolic regulation.

References : Buckeridge C. et al.: Hybrid 58th EASD Annual Meeting; Sept 19–23, (abstr 114), 2022; Sloop K. W. et al.: Sci. Transl. Med., 16(778), eadp5765, 2024.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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