Lovastatin-d3 (mixture of diastereomers)

SL-3509

Lovastatin-d₃ (mixture of diastereomers), >98% (CP)

Isotopic Purity : 98 atom % D

CAS No. : [1002345-93-8]

Synonyms : Mevinolin-d₃; Mevacor-d₃; MK-803-d₃; Simvastatin-d₃ EP impurity E

IUPAC Name : (1S,3R,7S,8S,8aR)-8-(2-((2S,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (S)-2-methylbutanoate

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Applications : Lovastatin-d₃ (mixture of diastereomers) is a deuterium labelled version of Lovastatin, which is an inhibitor of HMG-CoA reductase, used for lowering cholesterol (hypolipidemic agent).

References : Pahan K. et al.: J. Clin. Invest., 100(11), 2671-2679, 1997; Keyomarsi K. et al.: Cancer Res., 51(13), 3602-3609, 1991; Tobert J. A. et al.: Nat Rev Drug Discov., 2(7), 517-526, 2003.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.