LTA4H inhibitor

SI-7581

LTA4H inhibitor, >98% (HPLC)

IUPAC Name : 1-((5-((5-(1H-Pyrazol-5-yl)pyridin-2-yl)oxy)pyridin-2-yl)methyl)piperidin-4-ol

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a potent and selective LTA4H inhibitor derived from fragment‑based optimization. Strategic increases in polarity and incorporation of a basic amino group—forming a key H‑bond with Q136—boosted potency and drug‑likeness. It shows exceptional selectivity, demonstrates oral efficacy in a mouse arthritis model, and is predicted to require a 40 mg once‑daily human dose to maintain 90% target engagement, supporting its promise for chronic inflammatory diseases.

References : Thoma G. et al.: J. Med. Chem., 67(6), 5093-5108, 2024.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.