Lu AF-27139

SI-6521

Lu AF-27139, >98% (HPLC)

CAS No. : [2097117-06-9]

IUPAC Name : (S)-N-(2-(4-Chlorophenyl)-2-morpholinoethyl)-2-(pyrimidin-2-yl)-4-(trifluoromethyl)thiazole-5-carboxamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Lu AF-27139 is a potent, selective, and orally active P2X7 receptor antagonist with IC₅₀ values of 12 nM (human) and 2.4 nM (rat), and Kᵢ values of 22 nM (mouse), 54 nM (human), and 13 nM (rat). It is CNS‑penetrant, rodent‑active, and suitable for research in CNS disorders.

References : Hopper A. T. et al.: J. Med. Chem., 64(8), 4891-4902, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.