Lumacaftor-d4

SI-6561

Lumacaftor-d₄, >98% (HPLC)

CAS No. : [2733561-44-7]

Synonyms : VRT-826809-d₄; VX-809-d₄

IUPAC Name : 3-(6-(1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamido-2,2,3,3-d₄)-3-methylpyridin-2-yl)benzoic acid

Price And Availability
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5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : Lumacaftor‑d₄ is a deuterium-labelled version of Lumacaftor. This can be used as an analytical labelled reference standard. Lumacaftor acts as a CFTR‑corrector by improving the folding stability and intracellular trafficking of misprocessed CFTR protein, supporting restoration of CFTR function in cystic‑fibrosis models.

References : Russak E. M. et al.: Ann. Pharmacother., 53(2), 211-232, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.