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Lumateperone

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SL-9604

Lumateperone, >98%

CAS No. : [313368-91-1]

Synonyms : ITI-007

IUPAC Name : 1-(4-Fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)butan-1-one

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25MGRequest A Quote
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Chemical Properites
Mol. Formula :
C24H28FN3O
Mol. Weight :
393.51
Appearance :
Solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : Lumateperone is an orally active compound that acts as a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist at presynaptic D2 receptors, an antagonist at postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. It has been investigated for its anticancer properties and is also used in research related to schizophrenia and bipolar depression.

References : Zhang J. et al.: Mol Inform., e2200011, 2022; Titulaer J. et al.: Eur. Neuropsychopharmacol., 62, 22-35, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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