Lumateperone metabolite M309

SL-9616

Lumateperone metabolite M309, >98%

CAS No. : [2117618-98-9]

Synonyms : IC201309

IUPAC Name : (6bR,10aS)-8-(4-(4-Fluorophenyl)-4-hydroxybutyl)-6b,7,8,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-2(3H)-one

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Applications : This is a minor metabolite of Lumateperone, which is an orally active compound that acts as a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist at presynaptic D2 receptors, an antagonist at postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. Lumateperone has been investigated for its anticancer properties and is also used in research related to schizophrenia and bipolar depression.

References : Zhang J. et al.: Mol Inform., e2200011, 2022; Titulaer J. et al.: Eur. Neuropsychopharmacol., 62, 22-35, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.