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Luminespib

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SI-5756

Luminespib, >98% (HPLC)

CAS No. : [747412-49-3]

MDL No. : MFCD14635361

Synonyms : VER-52296; AUY922; NVP-AUY922

IUPAC Name : 5-(2,4-Dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide

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Chemical Properites
Mol. Formula :
C26H31N3O5
Mol. Weight :
465.55
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Luminespib is a potent Hsp90 inhibitor with IC50s of 7.8 and 21 nM for Hsp90α and Hsp90β, respectively. A promising anticancer agent.

References : Eccles Suzanne A. et al.: Cancer Research 68(8), 2850-2860, 2008; Best O. G. et al.: Leuk Lymphoma 53(11), 2314-20, 2012; Moser C. et al.: Anticancer Res., 32(7), 2551-61, 2012; Epp‐Ducharme B. et al.: Scientific Reports 11, Article No. 11103, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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