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Luvixasertib hydrochloride

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SI-6628

Luvixasertib hydrochloride, >98% (HPLC)

CAS No. : [1610677-37-6]

Synonyms : CFI-402257 hydrochloride

IUPAC Name : N-Cyclopropyl-4-(7-((((1s,3s)-3-hydroxy-3-methylcyclobutyl)methyl)amino)-5-(pyridin-3-yloxy)pyrazolo[1,5-a]pyrimidin-3-yl)-2-methylbenzamide hydrochloride

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Chemical Properites
Mol. Formula :
C28H30N6O3 • HCl
Mol. Weight :
535.05
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : CFI‑402257 hydrochloride targets TTK/Mps1 with low‑nanomolar potency (IC₅₀ = 1.7 nM) and is orally bioavailable. It effectively suppresses TTK‑driven mitotic signaling and displays robust anticancer efficacy in preclinical systems.

References : Liu Y. et al.: ACS. Med. Chem. Lett., 7(7), 671-5, 2016; Mason J. M. et al.: Proc. Natl. Acad. Sci., U S A. 114(12), 3127-3132, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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