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LY-294002 hydrochloride

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SI-7749

LY-294002 hydrochloride, >98% (HPLC)

CAS No. : [934389-88-5]

IUPAC Name : 2-Morpholino-8-phenyl-4H-chromen-4-one hydrochloride

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Chemical Properites
Mol. Formula :
C19H17NO3 • HCl
Mol. Weight :
343.81
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : LY-294002 hydrochloride inhibits PI3K isoforms with IC50 values of 0.5–0.97 µM and also blocks CK2 activity (IC50 = 98 nM). Its multi‑target profile and ability to disrupt key survival pathways support its use as a tool compound in pancreatic cancer research.

References : Bai R. et al.: Neoplasma, 63(1), 80-92, 2016; Chaussade C. et al.: Biochem. J. 404(3), 449-58, 2007; Gharbi S. I. et al.: Biochem. J. 404(1),15-21, 2007. Jiang H. et al:. J. Exp. Clin. Cancer Res., 29:34, 2010; Mokhtar A. H. et al.: Andrologia, 51(3), e13196, 2019; Hsueh Y. J. et al.: Mol. Ther. Methods Clin. Dev., 2, 15014, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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