M-525

SI-6652

M-525, >98% (HPLC)

CAS No. : [2173582-08-4]

IUPAC Name : Methyl ((1S,2R)-2-((S)-cyano(1-((1-(4-((1-((E)-4-(dimethylamino)but-2-enoyl)azetidin-3-yl)sulfonyl)phenyl)azetidin-3-yl)methyl)piperidin-4-yl)(3-fluorophenyl)methyl)cyclopentyl)carbamate

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : M‑525 potently and irreversibly inhibits the Menin–MLL interaction (IC₅₀= 3 nM) through covalent binding. It suppresses MLL‑fusion target gene expression, reduces leukemia‑cell proliferation at low‑nanomolar concentrations, and exhibits strong anti‑leukemia activity, underscoring its utility in Menin‑MLL–driven disease models.

References : Xu S. et al.: Angew. Chem. Int. Ed. Engl., 57(6), 1601-1605, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.