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Macitentan dimer

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SL-3518

Macitentan dimer, >98%

CAS No. : [2089065-77-8]

IUPAC Name : 5-(4-bromophenyl)-6-[2-[5-(4-bromophenyl)-6-(propylsulfamoylamino)pyrimidin-4-yl]oxyethoxy]-N-(propylsulfamoyl)pyrimidin-4-amine

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Chemical Properites
Mol. Formula :
C28H32Br2N8O6S2
Mol. Weight :
800.54
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Macitentan dimer is an impurity of Macitentan (Macitentan dimer impurity), which is an orally active, non-peptide endothelin receptor antagonist for the treatment of idiopathic pulmonary fibrosis and pulmonary arterial hypertension.

References : Iglarz M. et al. J. Pharmacol Exp Ther., 327(3), 736-745, 2008; Sen S. et al.: Life Sci., 91(13-14), 658-668, 2012; Kim S. J. et al.: Neoplasia., 13(2), 167-179, 2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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