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Macozinone

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SI-5921

Macozinone, >98% (HPLC)

CAS No. : [1377239-83-2]

MDL No. : MFCD28902203

Synonyms : PBTZ169

IUPAC Name : 2-(4-(Cyclohexylmethyl)piperazin-1-yl)-8-nitro-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one

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Chemical Properites
Mol. Formula :
C20H23F3N4O3S
Mol. Weight :
456.48
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Macozinone is a potent decaprenyl-phosphoribose-epimerase (DprE1) inhibitor, for the potential treatment of tuberculosis (TB).

References : Makarov V. et al.: EMBO Mol Med., 6(3), 372-83, 2014; Makarov V. et al.: Antimicrob Agents Chemother., 59(8), 4446-52, 2015; Gonzalez-Martínez N. A. et al.: PLoS Negl Trop Dis., 9(10), e0004022, 2015; Lechartier B. et al.: Antimicrob Agents Chemother., 59(8), 4457-63, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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