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MAK-683

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SI-6875

MAK-683, >98% (HPLC)

CAS No. : [1951408-58-4]

IUPAC Name : N-((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine

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Chemical Properites
Mol. Formula :
C20H17FN6O
Mol. Weight :
376.4
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : MAK-683 selectively inhibits EED with IC50 values of 59, 89, and 26 nM across AlphaScreen, LC‑MS, and ELISA assays. It serves as a valuable tool for probing PRC2/EED‑mediated epigenetic mechanisms.

References : Huang D. et al.: Chemphyschem., 21(3), 263-271, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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