MAP-855

SI-6995

MAP-855, >98% (HPLC)

CAS No. : [1660107-77-6]

IUPAC Name : 1-((3S,4S)-4-(8-(2-Chloro-4-(pyrimidin-2-yloxy)phenyl)-7-fluoro-2-methyl-1H-imidazo[4,5-c]quinolin-1-yl)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : MAP-855 functions as a highly potent, selective, and ATP‑competitive inhibitor of MEK1/2, showing strong suppression of the MEK1–ERK2 cascade (IC₅₀ = 3 nM) and downstream pERK signaling (EC₅₀ = 5 nM). It maintains equipotent activity across wild‑type and mutant MEK1/2 enzymes.

References : Poddutoori R. et al.: J. Med. Chem., 65(5), 4350-4366, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.