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Mavacamten-d6

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SL-9621

Mavacamten-d6, >98%

CAS No. : [2453251-18-6]

Related CAS No. : [1642288-47-8] of the unlabelled compound

Synonyms : SAR-439152-d6; MYK-461-d6

IUPAC Name : (S)-6-((1-Phenylethyl)amino)-3-(propan-2-yl-1,1,1,3,3,3-d6)pyrimidine-2,4(1H,3H)-dione

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Chemical Properites
Mol. Formula :
C15H13D6N3O2
Mol. Weight :
279.37
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a deuterium labelled version of Mavacamten, is a first-in-class cardiac myosin inhibitor used to treat adults with symptomatic obstructive hypertrophic cardiomyopathy (HCM).

References : Kawas R. F. et al.: J. Biol. Chem., 292(40), 16571-16577, 2017; Stern J. A. et al.: PLoS One 11(12), e0168407, 2016; Green E. M. et al.: Science 351(6273), 617-21, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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