Mcl‑1 inhibitor

SI-7914

Mcl‑1 inhibitor, >98% (HPLC)

IUPAC Name : N-((1S,4'R,8'R,Z)-6-Chloro-5'-fluoro-4'-methoxy-8'-methyl-10'-oxido-12'-oxo-1',2',3,3a',4,4',7',8',9',12',22',22a'-dodecahydro-2H,18'H,20'H-10'l6-spiro[naphthalene-1,19'-[13,16](metheno)furo[3,2-j][1,4]oxazepino[3,4-g][1]thia[2,8]diazacycloheptadecin]-10'-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a potent, selective small‑molecule Mcl‑1 inhibitor derived from an optimized non‑Lipinski azaindole series designed to enhance potency, physicochemical properties, and reduce cardiotoxicity risk. Despite residing in beyond‑Rule‑of‑Five space, the compound shows excellent oral bioavailability and delivers strong pharmacodynamic Mcl‑1 inhibition in a mouse xenograft model, resulting in robust tumor growth suppression. It represents a promising orally active Mcl‑1‑targeted anticancer lead for relapsed or refractory malignancies.

References : Romanov-Michailidis F. et al.: J. Med. Chem., 66(9), 6122-6148, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.