Mcl-1 inhibitor

SI-7936

Mcl-1 inhibitor, >98% (HPLC)

IUPAC Name : (R)-2³-Chloro-16-(4-fluorophenyl)-6⁴-((2-(2-methoxyphenyl)pyrimidin-4-yl)methoxy)-2²-methyl-4-(2-(4-methylpiperazin-1-yl)ethyl)-9-oxa-4-aza-1(5,4)-thieno[2,3-d]pyrimidina-2(1,4),6(1,3)-dibenzenacyclononaphane-8-carboxylic acid

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a potent macrocyclic inhibitor, incorporating a bicyclic thienopyrimidine pharmacophore and a strategically positioned carboxylic acid on the linker to enhance binding and polarity distribution. The macrocyclic architecture supports high affinity, conformational control, and improved drug‑like properties. This is a valuable research tool for exploring next‑generation macrocyclic inhibitor design.

References : Romanov-Michailidis F. et al.: J. Med. Chem., 66(9), 6122-6148, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.