MDM2-p53 inhibitor

SI-6487

MDM2-p53 inhibitor, >98% (HPLC)

CAS No. : [2814144-86-6]

IUPAC Name : (R)-6-((1-(4-Chlorophenyl)-7-fluoro-1-((1-(hydroxymethyl-d2)cyclopropyl)methoxy-d2)-5-(2-hydroxypropan-2-yl)-3-oxoisoindolin-2-yl)methyl)nicotinonitrile

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a stereodefined isoindolinone scaffold incorporating strategic deuterium labeling (cyclopropyl‑d₂, methoxy‑d₂) to enhance metabolic stability and enable PK/PD tracing. The structure integrates a 7‑fluoro isoindolinone core, a 4‑chlorophenyl moiety, and a nicotinonitrile substituent, supporting applications in oncology‑focused small‑molecule development, MDM2‑pathway interrogation, and isotopic profiling studies.

References : Chessari G. et al.: J. Med. Chem., 64(7), 4071−4088, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.