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Mefloquine

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SI-5551

Mefloquine, >98% (HPLC)

CAS No. : [53230-10-7]

IUPAC Name : (S)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((R)-piperidin-2-yl)methanol

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Chemical Properites
Mol. Formula :
C17H16F6N2O
Mol. Weight :
378.32
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Mefloquine is a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. Mefloquine can be used for malaria, systemic lupus erythematosus and cancer research.

References : Kang J. et al.: J Pharmacol Exp Ther., 299(1), 290-6, 2001; Yan K. H. et al.: Oncol Lett., 5(5), 1541-1545, 2013; Kaho Shionoya et al.: Front Microbiol. 12, 651403, 2021; Rafael Pacheco-Costa et al.: Bone 114, 22-31, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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