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SL-10995

Melflufen, >98%

CAS No. : [380449-51-4]

Synonyms : Melphalan flufenamide

IUPAC Name : (S)-1-Ethoxy-3-(4-fluorophenyl)-1-oxopropan-2-yl (S)-2-amino-3-(4-(bis(2-chloroethyl)amino)phenyl)propanoate

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Chemical Properites
Mol. Formula :
C24H29Cl2FN2O4
Mol. Weight :
499.4
Appearance :
Solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : Melflufen is a dipeptide prodrug of Melphalan, which functions as an alkylating agent. It exhibits antitumor activity against multiple myeloma (MM) cells and demonstrates inhibition of angiogenesis. Melflufen induces irreversible DNA damage and cytotoxicity in MM cells.

References : Chauhan D. et al.: Clin Cancer Res., 19(11), 3019-3031, 2013; Ray A. et al.: Br.J. Haematol., 174(3), 397-409, 2016; McAndrews K. M. et al.: Mol Cancer, 18(1), 52, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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