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Methazolamide-d6

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SI-5851

Methazolamide-d6, >98% (HPLC)

Isotopic Purity : 99 atom % D

CAS No. : [1795142-30-1]

IUPAC Name : (E)-N-(3-(Methyl-d3)-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide-d3

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Chemical Properites
Mol. Formula :
C5H2D6N4O3S2
Mol. Weight :
242.30
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Methazolamide-d6 is a deuterium labelled version an analog of Methazolamide, which is a sulfonamide derivative used as a carbonic anhydrase (CA) inhibitor with a Ki of 14 nM for human carbonic anhydrase II. Methazolamide, an intraocular pressure-lowering agent, reduces intraocular pressure elevations associated with glaucoma and other ocular disorders.

References : Yang F. et al.: Pharmacogenomics J. 16(1), 83-87, 2016; Abbate F. et al.: J. Enzyme Inhib Med Chem., 18(4), 303-308, 2003.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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