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Methazolamide unknown impurity

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Methazolamide unknown impurity, >98%

CAS No. : [109046-37-9]

Synonyms : 1,3,4-Thiadiazole, 2-(benzylthio)-5-N-methylacetamido-(6CI)

IUPAC Name : N-(5-(Benzylthio)-1,3,4-thiadiazol-2-yl)-N-methylacetamide

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Chemical Properites
Mol. Formula :
C12H13N3OS2
Mol. Weight :
279.38
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Methazolamide, which is a sulfonamide derivative used as a carbonic anhydrase (CA) inhibitor with a Ki of 14 nM for human carbonic anhydrase II. Methazolamide, an intraocular pressure-lowering agent, reduces intraocular pressure elevations associated with glaucoma and other ocular disorders.

References : Yang F. et al.: Pharmacogenomics J. 16(1), 83-87, 2016; Abbate F. et al.: J. Enzyme Inhib Med Chem., 18(4), 303-308, 2003.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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