Methotrexate impurity C

SL-8276

Methotrexate impurity C, >98%

CAS No. : [2410-93-7]

Synonyms : N10-Methyl folic acid; N10-Methylpteroylglutamic acid; NSC 107144; Methotrexate USP related compound C; Methotrexate EP impurity C

IUPAC Name : (4-(((2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid

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Applications : This is an impurity of Folic acid, which is an essential nutrient that belongs to the B complex group of vitamins. It demonstrates antidepressant-like effects and, in the form of folic acid sodium, helps lower the risk of neonatal neural tube defects. Additionally, folic acid is utilized in research related to megaloblastic and macrocytic anaemias that result from folic acid deficiency.

References : Butterworth C. E. Jr. et al.: Am. J. Clin Nutr., 50(2), 353-8, 1989; Brocardo P. S. et al.: Neuropharmacology 54(2), 464-73, 2008; Lillycrop K. A. et al.: J. Nutr., 135(6), 1382-6, 2005; Pietrzik K. et al.: Clin Pharmacokinet., 49(8), 535-48, 2010; Penalva R. et al.: Journal of Drug Delivery Science and Technology, 30, 450-457, 2015; Aparicio-Trejo O. E. et al.: Free Radic Biol Med., 154, 18-32, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.