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Methyl (R)-2-amino-3-(7-methyl-1H-indazol-5-yl)propanoate hydrochloride

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Methyl (R)-2-amino-3-(7-methyl-1H-indazol-5-yl)propanoate hydrochloride, >98%

Price And Availability
Pack SizePrice in USDAdd To Shopping CartAvailabilityShipping Status
100MGRequest A Quote
In Stock  Estimated to ship on 20 September 2026
250MGRequest A Quote
In Stock  Estimated to ship on 20 September 2026
500MGRequest A Quote
In Stock  Estimated to ship on 20 September 2026
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Chemical Properites
Mol. Formula :
C12H15N3O2 • HCl
Mol. Weight :
269.73
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an advanced key intermediate in the synthesis of Vazegepan and related analogs. Vazegepant is an orally active CGRP receptor antagonist used in migraine research and can also be given intranasally. CGRP plays a key role in migraine pathophysiology.

References : Moreno-Ajona D. et al.: Curr Opin Neurol., 33(3), 309-315, 2020; Gene M. D. et al.: Med Chem., 63(13), 6600-6623, 2020; Capi M. et al.: Springer International Publishing, 67-72, 2022; Jessica Barreto R. D. S. et al.: Eur. J. Pharmacol., 922, 174902, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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