Methyl (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionate

SL-5005

Methyl (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionate, >98%

CAS No. : [177036-78-1]

MDL No. : MFCD11865341

Synonyms : (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid methyl ester

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
1G	145.00		Back Order	Estimated to ship on 04 October 2026
5G	455.00		Back Order	Estimated to ship on 04 October 2026
10G	685.00		Back Order	Estimated to ship on 04 October 2026

Applications : This is an advanced key intermediate in the preparation of Ambrisentan, which is a highly selective antagonist of the endothelin-1 type A receptor (ETAR), used in the treatment of pulmonary arterial hypertension (PAH).

References : Weiss J. et al.: Eur J Pharmacol, 660(2-3), 298-304, 2011; Yokoyama Y. et al.: Biol Pharm Bull, 37(3), 461-465, 2014; Weiss J. et al.: Biochem Pharmacol, 85(2), 265-273, 2013; Osano A. et al.: J. Pharmacol Sci, 124(1), 86-91, 2014; Buckley M. S. et al.: Expert Opin Drug Metab Toxicol, 7(3), 371-380, 2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.