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MF-766

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SI-5635

MF-766, >98% (HPLC)

CAS No. : [1050656-06-8]

IUPAC Name : 4-(1-(1-(4-(Trifluoromethyl)benzyl)-1H-indole-7-carboxamido)cyclopropyl)benzoic acid

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Chemical Properites
Mol. Formula :
C27H21F3N2O3
Mol. Weight :
478.47
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : MF-766 is a highly potent, selective and orally active EP4 antagonist with a Ki of 0.23 nM. MF-766 behaves as a full antagonist with an IC50 of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay. MF-766 can be used for cancer and inflammation diseases research.

References : Colucci J. et al.: Bioorg Med Chem Lett., 20(12), 3760-3, 2010; Wang Y. et al.: Oncoimmunology 10(1), 1896643, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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