MG-132

SI-5727

MG-132, >98% (HPLC)

CAS No. : [133407-82-6]

MDL No. : MFCD00674886

Synonyms : Z-Leu-Leu-Leu-al; MG13

IUPAC Name : Benzyl ((S)-4-methyl-1-(((S)-4-methyl-1-(((S)-4-methyl-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)carbamate

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
1G	Request A Quote		Back Order	Estimated to ship on 04 October 2026
5G	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : MG-132 is a potent proteasome and calpain inhibitor with IC₅₀s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132 is a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis.

References : Harhouri K. et al.: EMBO Mol Med., 9(9), 1294-1313., 2017; Fan W. H. et al.: Acta Pharmacol Sin., 32(5), 619-25, 2011; Tsubuki S. et al.: J. Biochem., 119(3), 572-6, 1996; Fiedler M. A. et al.: Am. J. Respir Cell Mol Biol., 19(2), 259-68, 1998; MacLaren A. P. et al.: Cell Death Differ., 8(3), 210-8, 2001; Han Y. H. et al.: Oncol Rep., 22(1), 215-21, 2009; Dang L. et al.: Int J Mol Med., 33(5), 1083-8, 2014; Matsumoto Y. et al.: Cancer Sci. 107(6), 773-81, 2016; Bonuccelli G. et al.: Am J Pathol., 163(4), 1663-75, 2003.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.