MI-136

SI-6648

MI-136, >98% (HPLC)

CAS No. : [1628316-74-4]

IUPAC Name : 5-((4-((6-(2,2,2-Trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : MI‑136 targets the Menin–MLL interaction with low‑nanomolar potency (IC₅₀ = 31 nM; Kd = 23.6 nM). Beyond its activity in MLL‑driven pathways, it blocks AR signaling, making it a useful tool for exploring Menin‑dependent transcriptional programs and castration‑resistant tumor biology.

References : Dmitry Borkin. et al.: J. Med. Chem., 59(3), 892-913, 2016; Rohit Malik. et al.: Nat. Med., 21(4), 344-52, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.