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MI-773

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SI-6503

MI-773, >98% (HPLC)

CAS No. : [1303607-07-9]

IUPAC Name : (2'R,3S,4'S,5'R)-6-Chloro-4'-(3-chloro-2-fluorophenyl)-N-((1r,4R)-4-hydroxycyclohexyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide

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Chemical Properites
Mol. Formula :
C29H34Cl2FN3O3
Mol. Weight :
562.51
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : MI‑773 is an oral, selective MDM2 inhibitor (Ki= 0.88 nM) that activates p53, induces apoptosis, and shows efficacy in adenoid cystic carcinoma and neuroblastoma.

References : Zhang Q. et al.: Subcell Biochem., 85, 281-319, 2014; Grigoreva A. T. et al.: 30(6), 785-797, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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