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MI-773 TFA

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SI-6504

MI-773 TFA, >98% (HPLC)

CAS No. : [1303609-37-1]

IUPAC Name : (2'R,3S,4'S,5'R)-6-Chloro-4'-(3-chloro-2-fluorophenyl)-N-((1r,4R)-4-hydroxycyclohexyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide 2,2,2-trifluoroacetate

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Chemical Properites
Mol. Formula :
C29H34Cl2FN3O3 • CF3CO2H
Mol. Weight :
676.53
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : MI‑773 TFA is an oral, selective MDM2 inhibitor (Ki= 0.88 nM) that activates p53, induces apoptosis, and shows efficacy in adenoid cystic carcinoma and neuroblastoma.

References : Warner K. A. et al.: Clin. Cancer Res., 22(14), 3550-3559, 2016; Chen Y. L. et al.: Oncol. Lett., 22(6), 838, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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