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Milvexian TFA

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SI-6927

Milvexian TFA, >98% (HPLC)

CAS No. : [1802426-00-1]

Synonyms : BMS-986177 TFA; JNJ-70033093 TFA

IUPAC Name : (5R,9S)-9-(4-(5-Chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl)-6-oxopyrimidin-1(6H)-yl)-21-(difluoromethyl)-5-methyl-21H-3-aza-1(4,2)-pyridina-2(5,4)-pyrazolacyclononaphan-4-one trifluoroacetate

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25MGRequest A Quote
Back Order  Estimated to ship on 04 October 2026
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250MGRequest A Quote
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Back Order  Estimated to ship on 04 October 2026
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Chemical Properites
Mol. Formula :
C28H23Cl2F2N9O2 • CF3CO2H
Mol. Weight :
740.47
Appearance :
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Milvexian TFA is a potent factor XIa inhibitor with demonstrated efficacy in preventing venous thromboembolism (VTE). It significantly reduced VTE incidence in patients undergoing knee replacement surgery, shows good selectivity with notable inhibition of plasma kallikrein and trypsin, has an oral bioavailability of 32%, and exhibits a relatively low bleeding risk in clinical studies.

References : Pancras C. Wong et al.: Milvexian for the Prevention of Venous Thromboembolism; Xinkang W. et al.: T. H. Open., 7(2), e97–e104, 2023; Wong P. et al.: Res. Pract. Thromb. Haemost., 4 (Suppl 1), 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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