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Miransertib

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SI-6457

Miransertib, >98% (HPLC)

CAS No. : [1313881-70-7]

Synonyms : ARQ-092

IUPAC Name : 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine

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Chemical Properites
Mol. Formula :
C27H24N6
Mol. Weight :
432.53
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Miransertib selectively inhibits Akt1/2/3 with low‑nanomolar potency and strongly suppresses the AKT1‑E17K mutant. It is under investigation for PI3K/Akt‑driven tumors and Proteus syndrome and demonstrates additional efficacy against Leishmania, highlighting its versatility across oncology and infectious‑disease models.

References : Lapierre J. M. et al.: J. Med. Chem., 59(13), 6455-69, 2016; Devki Nandan et al.: PLoS One., 13(11), e0206920, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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