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CAS No. : [1312691-33-0]
Synonyms : TAK-659; CB-659
IUPAC Name : 6-(((1R,2S)-2-Aminocyclohexyl)amino)-7-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one
| Price And Availability | ||||
|---|---|---|---|---|
| Pack Size | Price in USD | Add To Shopping Cart | Availability | Shipping Status |
| 25MG | Request A Quote | Back Order | Estimated to ship on 04 October 2026 | |
| 50MG | Request A Quote | Back Order | Estimated to ship on 04 October 2026 | |
| 100MG | Request A Quote | Back Order | Estimated to ship on 04 October 2026 | |
| 250MG | Request A Quote | Back Order | Estimated to ship on 04 October 2026 | |
| 500MG | Request A Quote | Back Order | Estimated to ship on 04 October 2026 | |
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| Chemical Properites | |
|---|---|
Mol. Formula : C17H21FN6O | Mol. Weight : 344.39 |
Appearance : Solid | Melting Point : Not available |
| For Laboratory research use only, not for drug, household or other uses. | |
Applications : TAK‑659 potently and selectively inhibits SYK and FLT3 at low‑nanomolar concentrations and triggers apoptosis preferentially in tumor cells. Its dual‑kinase activity and oral availability make it a valuable tool for studying CLL and related hematologic cancers.
References : Lam B. et al.: Bioorg. Med. Chem. Lett., 26(24), 5947-5950, 2016; Purroy N. et al.: Oncotarget., 8(1), 742-756, 2017; Yu J. et al.: Journal of Clinical Oncology, 34(15), e14091, 2016; Cen O. et al.: mSphere., 3(4), 2018.
Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.
Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.
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