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Mivavotinib

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SI-6313

Mivavotinib, >98% (HPLC)

CAS No. : [1312691-33-0]

Synonyms : TAK-659; CB-659

IUPAC Name : 6-(((1R,2S)-2-Aminocyclohexyl)amino)-7-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one

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25MGRequest A Quote
Back Order  Estimated to ship on 04 October 2026
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100MGRequest A Quote
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250MGRequest A Quote
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Back Order  Estimated to ship on 04 October 2026
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Chemical Properites
Mol. Formula :
C17H21FN6O
Mol. Weight :
344.39
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : TAK‑659 potently and selectively inhibits SYK and FLT3 at low‑nanomolar concentrations and triggers apoptosis preferentially in tumor cells. Its dual‑kinase activity and oral availability make it a valuable tool for studying CLL and related hematologic cancers.

References : Lam B. et al.: Bioorg. Med. Chem. Lett., 26(24), 5947-5950, 2016; Purroy N. et al.: Oncotarget., 8(1), 742-756, 2017; Yu J. et al.: Journal of Clinical Oncology, 34(15), e14091, 2016; Cen O. et al.: mSphere., 3(4), 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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