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MK-0159

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SI-7127

MK-0159, >98% (HPLC)

CAS No. : [2641484-61-7]

IUPAC Name : N-((1r,4r)-4-(2-Methoxyethoxy)cyclohexyl)-6-(thiazol-5-yl)-1H-pyrrolo[2,3-b]pyridine-4-carboxamide

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Chemical Properites
Mol. Formula :
C20H24N4O3S
Mol. Weight :
400.5
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : MK‑0159 potently and selectively inhibits CD38 across species and displays strong microsomal stability in human and rodent systems. It modulates NAD⁺ metabolism by increasing NAD⁺ and lowering ADPR in blood and heart tissues.

References : Lagu B. et al.: J. Med. Chem., 65(13), 9418-9446, 2022; Chen P. M. et al.: Sci. Adv., 8(24), eabo4271, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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