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MK-0941 free base

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SI-7717

MK-0941 free base, >98% (HPLC)

CAS No. : [752240-01-0]

IUPAC Name : (S)-3-((6-(Ethylsulfonyl)pyridin-3-yl)oxy)-5-((1-hydroxypropan-2-yl)oxy)-N-(1-methyl-1H-pyrazol-3-yl)benzamide

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Chemical Properites
Mol. Formula :
C21H24N4O6S
Mol. Weight :
460.51
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : MK‑0941 free base activates recombinant human glucokinase with EC50 values of 240 nM (2.5 mM glucose) and 65 nM (10 mM glucose). It demonstrates strong glucose‑lowering efficacy and represents a potential agent for type 2 diabetes therapy.

References : Eiki J. et al.: Mol. Pharmacol., 80(6), 1156-65, 2011; Meininger G. E. et al.: Diabetes Care, 34(12), 2560-6, 2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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