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MK-2894 sodium salt

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SI-5634

MK-2894 sodium salt, >98% (HPLC)

CAS No. : [1006036-88-9]

MDL No. : MFCD18251428

IUPAC Name : Sodium 4-(1-(2,5-dimethyl-4-(4-(trifluoromethyl)benzyl)thiophene-3-carboxamido)cyclopropyl)benzoate

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Chemical Properites
Mol. Formula :
C25H21F3NNaO3S
Mol. Weight :
495.49
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : MK-2894 sodium salt is a potent, selective, orally active and high affinity (Ki=0.56 nM) full antagonist against E prostanoid receptor 4 (EP4 receptor) (IC50=2.5 nM). MK-2894 sodium salt possesses potent anti-inflammatory activity in animal models of pain/inflammation and can be used for the research of arthritis.

References : Blouin M. et al.: J. Med Chem., 53(5), 2227-38, 2010; Markovic T. et al.: Drug Discov Today 22(1), 57-71, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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