MK-4074

SI-6086

MK-4074, >98% (HPLC)

CAS No. : [1039758-22-9]

IUPAC Name : 5-(1'-(1-Cyclopropyl-4-methoxy-3-methyl-1H-indole-6-carbonyl)-4-oxospiro[chromane-2,4'-piperidin]-6-yl)nicotinic acid

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : MK‑4074 selectively inhibits the liver‑localized ACC1 and ACC2 enzymes with low‑nanomolar potency (IC₅₀ ≈ 3 nM). Its strong hepatoselectivity makes it a valuable tool for probing ACC‑regulated pathways in fatty‑acid synthesis and hepatic metabolic disorders.

References : Kim C. W. et al.: Cell Metab., 26(2), 394-406.e6, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.