MK-4334

SI-7444

MK-4334, >98% (HPLC)

IUPAC Name : 4-((1S,3S)-2,2-Difluoro-3-(3-isopropyl-1,2,4-oxadiazol-5-yl)cyclopropyl)benzenesulfonamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : MK‑4334 is a small‑molecule RORγt modulator developed by Merck, reported in early discovery programs exploring retinoid‑related orphan receptor γt as a target for autoimmune and inflammatory diseases. Although detailed public data remain limited, MK‑4334 is generally described as a potent, selective RORγt inverse agonist designed to suppress Th17‑driven cytokine signaling. It represents one of the early proprietary scaffolds used to validate RORγt inhibition as a therapeutic strategy.

References : Ledneczki I. et al.: J. Med Chem., 66(23), 16276-16302, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.