MK‑8141

SI-7161

MK‑8141, >98% (HPLC)

CAS No. : [903579-36-3]

Synonyms : ACT-077825

IUPAC Name : (1S,5R)-N-Cyclopropyl-7-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)phenyl)-N-(2,3-dimethylbenzyl)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxamide

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25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : MK‑8141 increases ir‑renin levels substantially but does not achieve durable PRA inhibition. As a result, studies in hypertensive subjects showed no significant reduction in blood pressure, highlighting the requirement for sustained PRA suppression for renin‑targeted antihypertensive activity.

References : Jones-Burton C. et al.: J. Am. Soc. Hypertens, 4(5), 219-26, 2010.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.