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MLN-8054

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SI-4897

MLN-8054, >98% (HPLC)

CAS No. : [869363-13-3]

MDL No. : MFCD11840561

Synonyms : MLN8054

IUPAC Name : 4-((9-Chloro-7-(2,6-difluorophenyl)-5H-benzo[c]pyrimido[4,5-e]azepin-2-yl)amino)benzoic acid

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Chemical Properites
Mol. Formula :
C25H15ClF2N4O2
Mol. Weight :
476.86
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : MLN-8054 is a potent, selective and orally available aurora A kinase inhibitor with an IC50 of 4 nM.

References : Manfredi M. G.: et al. Proc Natl Acad Sci U S A, 104(10), 4106-4111, 2007; Moretti L. et al.: Int J. Radiat Oncol Biol Phys, 80(4), 1189-1197, 2011; Huck J. J. et al.: Mol Cancer Res, 8(3), 373-384, 2010.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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