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MNL-4760

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SI-5823

MNL-4760, >98% (HPLC)

CAS No. : [305335-31-3]

MDL No. : MFCD00058004

IUPAC Name : ((S)-1-Carboxy-2-(1-(3,5-dichlorobenzyl)-1H-imidazol-5-yl)ethyl)-L-leucine

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Chemical Properites
Mol. Formula :
C19H23Cl2N3O4
Mol. Weight :
428.31
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : MLN-4760 is a potent and selective human ACE2 inhibitor (IC50, 0.44 nM), with excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 μM) and bovine carboxypeptidase A (CPDA; IC50, 27 μM).

References : Dales N. A. et al.: J. Am. Chem. Soc., 124(40), 11852-3, 2002; Joshi S. et al.: Eur. J. Pharmacol., 774, 25-33, 2016; Bennion D. M. et al.: Hypertension 66(1), 141-8, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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