Mono-POC ethyl tenofovir (mixture of diastereomers)

SL-1849

Mono-POC ethyl tenofovir (mixture of diastereomers), >98%

CAS No. : [1796539-92-8]

Synonyms : (8R)-9-(6-Amino-9H-purin-9-yl)-5-ethoxy-8-methyl-2,4,7-trioxa-5-phosphanonanoic acid methyl 1-methylethyl ester 5-oxide; [Isopropylcarbonyloxymethyl-(ethoxy)-[(R)-9-(2-phosphonomethoxy)]propyl adenine; Tenofovir ethyl monoisoproxil

IUPAC Name : ((((((R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(ethoxy)phosphoryl)oxy)methyl isopropyl carbonate

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Applications : This is an analog of Tenofovir, which is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B.

References : Shaw J. P. et al.: Pharm. Res., 14, 1824,1997; Wyles D. et al.: Clin Infect. Dis., 40, 174, 2005.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.