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Mosapride citrate

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Mosapride citrate, >98%

CAS No. : [112885-42-4]

Synonyms : TAK-370 citrate; AS-4370 citrate

IUPAC Name : 4-Amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)morpholin-2-yl)methyl)benzamide 2-hydroxypropane-1,2,3-tricarboxylate

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Chemical Properites
Mol. Formula :
C21H25ClFN3O3 • C6H8O7
Mol. Weight :
614.02
Appearance :
Solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : Mosapride citrate is an orally active gastroenterokinetic agent that acts as a 5HT4 agonist and a CYP inducer. It exhibits concentration-dependent inhibition of Kv4.3 channels, with an IC50 of 15.2 μM. Mosapride is useful for research related to gastrointestinal diseases.

References : Tack J. et al.: Aliment Pharmacol Ther., 35(7), 745-67, 2012; Curran M. P. et al. Drugs 68(7), 981-91, 2008; Kim H. S. et al.: Neurogastroenterol Motil., 20(2), 169-76, 2008;
Kim Y. H. et al. Biomol Ther (Seoul)., 23(5), 486-92, 2015; Uchida M. et al.: J. Pharmacol Sci., 121(4), 282-7, 2013; Fujisawa M. et al.: J. Gastroenterol., 45(2), 179-86, 2010; Sung K. W. et al.: Naunyn Schmiedebergs Arch Pharmacol., 386(10), 905-16, 2013.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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